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USP <232> Elemental Impurities — Limits

Issued by United States Pharmacopeia (USP)

Standard

Audit Scope

Sets permitted daily exposure (PDE) limits for elemental impurities (arsenic, cadmium, lead, mercury, and additional Class 2A/2B/3 elements) in pharmaceutical and dietary supplement products.

What It Proves

A product or ingredient manufacturer has tested against USP-specified elemental-impurity limits and met the published PDE thresholds for the dose form and route of administration in question.

What It Does Not Prove

USP <232> is a STANDARD, not a certification. There is no USP-issued <232> certificate. Vendor claims of '<232> compliant' are self-declarations unless paired with a third-party laboratory result (ISO/IEC 17025 accredited) showing test methodology (USP <233>) and quantitative results below PDE thresholds. Self-declaration alone is unverifiable.

How Vendors Report It

You may see this listed as:

USP <232>USP 232USP General Chapter <232>
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