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USP <233> Elemental Impurities — Procedures

Issued by United States Pharmacopeia (USP)

Standard

Audit Scope

Specifies analytical procedures (ICP-MS and ICP-OES) for quantifying elemental impurities defined in USP <232>. Includes sample preparation, instrument validation, system suitability, and acceptance criteria.

What It Proves

A laboratory used USP-specified ICP-MS or ICP-OES procedures (with validated methodology) to quantify elemental impurities in a sample.

What It Does Not Prove

USP <233> describes METHODS, not pass/fail thresholds (those are in <232>). A '<233> tested' claim without paired <232> result interpretation is incomplete. A lab performing <233> procedures must be ISO/IEC 17025 accredited for the specific test scope for results to be third-party defensible; in-house <233> is self-declaration.

How Vendors Report It

You may see this listed as:

USP <233>USP 233USP General Chapter <233>
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