Nitrosigine®
inositol-stabilized arginine silicate
Arginine SilicateLast reviewed: July 11, 2026
Medical & Industry Advisor: Dr. James Pendleton, ND
Answer
Availability
We have not verified a current supply status for this ingredient. Unknown is our default: we publish a status only with dated evidence. If you have first-hand sourcing information, use the correction link below.
Owner and access
- Owner
- Nutrition21, LLC (site)
- Access model
- Licensed program
What it is
- Trademark held by Nutrition21, LLC; the brand portfolio is commercially operated by Everwell Health (the former nutrition21.com now redirects to everwellhealth.com). [everwellhealth.com footer]
Spec parameters buyers should demand
What to ask for on the certificate of analysis and spec sheet. Identity, quality, and regulatory parameters only. This is not advice about efficacy.
| Parameter | What to ask | Why it matters |
|---|---|---|
| Component identity (arginine, silicate, inositol) | Nitrosigine is described by the brand as a bonded arginine silicate complex, inositol-stabilized. Ask the certificate of analysis to document the arginine, silicate, and inositol components and the assay methods used for each.[everwellhealth.com — Nitrosigine] | A multi-component bonded complex is defined by its constituents; a CoA that documents each component is what lets you verify you received the specified material rather than a plain arginine salt. |
| Identity verification | Confirm the manufacturer runs at least one validated identity test on each incoming lot, as 21 CFR 111.75(a)(1) requires for every dietary ingredient. USP publishes an L-Arginine Reference Standard for the arginine component.[USP L-Arginine Reference Standard] | Identity testing is a federal manufacturing requirement, and named methods for the arginine component give your quality file a compendial anchor. |
| US regulatory footing (NDI) | Ask whether the arginine silicate carries an FDA New Dietary Ingredient (NDI) notification and request the documentation. Nitrosigine reached the market following an FDA-acknowledged NDI notification and is marketed with a self-affirmed GRAS determination.[everwellhealth.com — Nitrosigine brand page] | A novel bonded-mineral complex is the class of ingredient the NDI pathway exists for; the notification records its US regulatory standing for your due-diligence file. |
| Heavy metals | Request lead, arsenic, cadmium, and mercury results with the test method and the limits applied.[21 CFR Part 111 — cGMP for dietary supplements] | Heavy-metal control is a baseline quality attribute for any bulk ingredient and part of a complete certificate of analysis under 21 CFR Part 111. |
QC and testing considerations
- Every dietary ingredient must pass at least one validated identity test before use (21 CFR 111.75(a)(1)). For a bonded complex, confirm identity is verified on each incoming lot, not only at supplier qualification. [21 CFR 111.75(a)(1)]
- Ask the supplier to document each component of the complex (arginine, silicate, inositol) on the CoA so a plain arginine salt cannot be substituted under the branded name. [everwellhealth.com — Nitrosigine]
- Request the FDA NDI notification and GRAS documentation on file so your regulatory record for the ingredient is complete. [everwellhealth.com — Nitrosigine brand page]
Further reading: How to read a certificate of analysis and third-party supplement testing.
Reference list
- USP L-Arginine Reference Standard (compendial identity/assay standard for the arginine component, CAS 74-79-3) Pharmacopeia
- 21 CFR Part 111 — Current Good Manufacturing Practice for dietary supplements (identity testing at 111.75) Regulatory
- Nitrosigine (Nutrition21 / Everwell Health) — branded bonded arginine silicate, owner site Owner technical
A reference list is not claim substantiation. Under the FTC's Health Products Compliance Guidance (December 2022), marketing claims about a finished product require competent and reliable scientific evidence, typically randomized, controlled human clinical testing. Responsibility for substantiating product claims rests with the brand.
Manufacturers with stated capability
No manufacturer has a listed capability for this ingredient yet. Listings are positive-only: an entry states a manufacturer can run the ingredient, never that one cannot.
Run this ingredient? Request inclusion.
Further reading
The decision framework behind this reference: five checkable criteria for choosing between a branded ingredient and its generic form.
What this page does not tell you
- Whether the owner will license your specific product or accept a new account.
- Pricing, minimum order volumes, or contract terms.
- Anything about efficacy. This is an identity and sourcing reference.
Prefills the ingredient into the RFQ Spec Builder. You enter your own formula; the tool formats it into a spec sheet.
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