Testing & Stability Labs

Independent analytical laboratories that verify supplement identity, potency, purity, and safety. Accredited testing for regulatory compliance, quality assurance, and stability studies including accelerated and real-time shelf-life protocols.

Independent testing is how you prove what's in your product. Stability testing is how you prove it stays that way. This page explains what testing and stability labs do, how to evaluate them, and what separates a credible lab from one that just prints numbers on paper.

Dietary supplement manufacturers must comply with 21 CFR Part 111 (Current Good Manufacturing Practice for dietary supplements). This includes requirements for personnel, facilities, equipment, production, laboratory operations, and record-keeping.

What Testing Is Required Under Part 111

21 CFR Part 111 requires dietary supplement manufacturers to test at multiple stages of production. These are not optional. They are federal requirements.

StageWhat Must Be TestedCFR Reference
Incoming ingredientsIdentity of each lot (every component)111.75(a)(1)
In-processVerification that specs are met during production111.75(b)
Finished productIdentity, purity, strength, composition, contamination111.75(c)
Packaging and labelingCorrect label for correct product111.75(g)

Types of Tests and What They Measure

Identity Testing

Measures: Confirms the ingredient is what it claims to be

Methods: HPTLC, HPLC, DNA barcoding (for botanicals), FTIR

Why it matters: Prevents wrong ingredients from entering your product. The most fundamental quality test.

Potency / Assay Testing

Measures: Quantifies the amount of active ingredient per serving

Methods: HPLC, UV-Vis spectrophotometry, titration

Why it matters: Proves your label claims are accurate. Under-potency or over-potency are both compliance failures.

Microbial Testing

Measures: Detects harmful microorganisms (bacteria, yeast, mold)

Methods: Total plate count, USP methods, PCR-based detection

Why it matters: Protects consumer safety. Contamination can cause illness and triggers recalls.

Heavy Metals

Measures: Lead, mercury, cadmium, arsenic levels

Methods: ICP-MS, ICP-OES

Why it matters: Required for California Prop 65 compliance. Many retailers require this for product listing.

Pesticide Residue

Measures: Traces of agricultural chemicals

Methods: GC-MS/MS, LC-MS/MS

Why it matters: Important for botanicals and plant-based ingredients. Required for organic certification.

Stability Study Types

Your expiration date is only as good as the data behind it. Stability testing measures how temperature, humidity, light, and time affect your product's potency, purity, and physical characteristics.

Accelerated Stability

Elevated conditions (40°C/75% RH) for 3-6 months. Predicts product behavior under stress. Used for preliminary shelf-life estimates and to identify potential degradation pathways early. Results available faster but less precise than real-time data.

Real-Time (Long-Term) Stability

Normal storage conditions (25°C/60% RH) for 12-36 months. The most accurate predictor of actual shelf life. Required for final expiration date assignment. Typically run in parallel with accelerated studies.

Intermediate Stability

Moderate conditions (30°C/65% RH) for 12 months. Used when accelerated data shows significant change, providing additional data between accelerated and long-term conditions. Helps refine shelf-life predictions.

Photostability

Measures degradation from light exposure. Critical for light-sensitive ingredients (B vitamins, omega-3s, certain botanicals). Tests both the product and the packaging's ability to protect against light.

How to Evaluate a Testing Lab

  • ISO/IEC 17025 accreditation: This is the gold standard for testing laboratories. It means the lab's methods, equipment, and personnel have been validated by an independent accreditation body. Check A2LA or ANAB directories to verify.
  • Scope of accreditation: A lab can be ISO 17025 accredited for some tests but not others. Check that their accreditation covers the specific tests you need. An accredited microbial lab may not be accredited for heavy metals.
  • Experience with dietary supplements: Not all analytical labs specialize in supplements. Look for labs that routinely handle botanical identification, USP reference standards, and Part 111 requirements.
  • Stability chamber capabilities: For stability testing, chambers must maintain precise temperature and humidity. Ask about chamber calibration frequency, monitoring systems, and what happens during power outages. ICH-compliant chambers are the standard.
  • Turnaround time and communication: Standard turnaround is 5 to 10 business days. The lab should provide clear timelines and communicate proactively about delays or out-of-spec results.
  • COA format and detail: Request a sample COA before you commit. It should include method references, specification limits, actual results, and authorized signatures. Template or minimal COAs are a yellow flag.

Disclaimer: This page is educational content, not professional advice. Testing and stability requirements vary by product, ingredients, and regulatory jurisdiction. Consult qualified professionals. See our Terms of Service for details.

Assessed Vendors

Showing 7 of 7 vendors

Eurofins Scientific operates a global network of over 900 laboratories across 62 countries. Their US supplement testing is anchored by the ISO/IEC 17025 accredited Eurofins Nutrition Analysis Center in Des Moines, Iowa, and the Eurofins Food Chemistry Testing lab (formerly Covance Food Solutions) in Madison, Wisconsin. Eurofins provides identity, potency, purity, stability, and contaminant testing for dietary supplements using HPLC, UPLC, GC, LCMS, and ICP-MS technologies. They test botanicals, vitamins, minerals, sports nutrition products, and pet supplements. Their stability testing services include both accelerated and real-time shelf-life studies. Eurofins is publicly traded (EUFI.PA) and employs over 62,000 people globally, making them one of the largest testing organizations in the world. This scale provides redundancy and capacity but may mean less personalized service for smaller supplement brands.

Min. Order

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Lead Time

5-10 business days (standard), varies for stability

Identity TestingPotency TestingHeavy MetalsMicrobial TestingStability StudiesPesticide ResiduesShelf-Life Studies
ISO/IEC 17025

Assessed Mar 2026

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NSF International is an independent, not-for-profit organization founded in 1944 in Ann Arbor, Michigan. Their dietary supplement testing division operates ISO/IEC 17025 accredited laboratories that test products against NSF/ANSI 173, the only American National Standard for dietary supplement ingredients. NSF tests for label accuracy, contaminant screening (heavy metals, pesticides, mycotoxins, microbial), and banned substances through their Certified for Sport program. NSF is widely recognized by retailers and regulators — many major retail chains require NSF GMP certification as a baseline for supplement listing. Their lab network spans North America, Europe, and China, with ingredient testing available through their Shanghai facility for brands sourcing from Asia. NSF also operates the GMP facility certification program that many contract manufacturers pursue.

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Label Accuracy TestingContaminant ScreeningBanned Substance TestingMicrobial TestingHeavy MetalsPesticide Testing
ISO/IEC 17025

Assessed Mar 2026

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Harrisburg, Pennsylvania

How We Get Paid

SGS Nutrasource combines regulatory consulting, clinical trial management, and laboratory testing for the nutraceutical industry. Originally founded as Nutrasource Diagnostics in Guelph, Ontario, the company was acquired by SGS SA in May 2023, giving it access to SGS's global network of 2,600+ laboratories in 100+ countries. Their Harrisburg, Pennsylvania laboratory is ISO/IEC 17025 accredited and specializes in heavy metals, minerals, and vitamins testing of dietary supplements. SGS Nutrasource has supported over 20,000 product launches and completed more than 1,700 clinical trials for claim substantiation. They operate proprietary certification programs including IFOS (fish oils), IKOS (krill oils), IGEN (non-GMO), and IPRO (probiotics). The company serves 2,000+ clients globally across dietary supplements, pet supplements, pharmaceuticals, cosmetics, and infant nutrition.

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Heavy Metals TestingVitamins AnalysisMinerals TestingClinical Trial ServicesProduct Certification
ISO/IEC 17025

Assessed Mar 2026

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Canton, Massachusetts

How We Get Paid

UL Solutions (formerly Underwriters Laboratories) is a global safety science company that operates an FDA-registered dietary supplement testing laboratory in Canton, Massachusetts. UL technicians use industry-approved methodologies including DNA testing for botanical identity verification, potency analysis, and contaminant screening for heavy metals, pesticides, and microbial hazards. UL offers a Dietary Supplement Verified Mark program — brands that participate and qualify can display the UL Verified mark on their products, providing third-party verification of quality and label accuracy. NOW Foods is a notable brand that holds UL dietary supplement certification. UL has been in operation since 1894 and employs over 15,000 people worldwide. Their supplement testing division is smaller relative to their electrical safety and consumer product testing businesses, but carries the weight of a globally recognized certification mark.

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Identity TestingPotency TestingHeavy MetalsPesticide ResiduesMicrobial TestingDNA Testing (Botanicals)

Assessed Mar 2026

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Garden Grove, California

How We Get Paid

Alkemist Labs is an independent botanical and mushroom testing laboratory in Garden Grove, California. Founded by Elan Sudberg, the company specializes in identity and potency testing for natural products using HPTLC (High Performance Thin-Layer Chromatography), microscopy, and HPLC methods. Their ISO/IEC 17025 accreditation through A2LA specifically covers dietary supplement and botanical identification — a focused scope that reflects their deep specialization. Alkemist Labs maintains one of the largest collections of analyzed and verified botanical reference materials in the industry, containing over 15,000 specimens spanning 20 years. This collection is critical for identity testing accuracy. AG1 (Athletic Greens) is a notable client. Alkemist publishes a biannual report on the top botanicals and fungi that commonly fail identity testing, providing transparency that is rare in the testing industry. They are a smaller, specialized lab compared to Eurofins or SGS, which means more personalized service but potentially longer wait times during peak demand.

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Botanical Identity TestingPotency TestingHPTLC AnalysisMicroscopyMushroom Testing
ISO/IEC 17025 (A2LA)

Assessed Mar 2026

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Champaign, Illinois

How We Get Paid

Intertek's Champaign, Illinois laboratory specializes in analytical testing of nutraceuticals, botanicals, and natural products. With more than 15 years of supplement-specific experience, the lab offers identity, potency, purity, safety, and shelf-life testing. Their capabilities span analytical chemistry, botanical chemistry, analytical biochemistry, and microbiology. Intertek also provides label review and validation services, allergen testing, contaminant and adulterant risk management, and method development. Globally, Intertek Group plc operates more than 1,000 laboratories with over 45,000 employees. The Champaign lab holds ISO/IEC 17025 accreditation and operates under cGMP. Their 2022 launch of an adulteration panel analysis for nutraceutical supplements demonstrates investment in supplement-specific testing innovation. Like Eurofins and SGS, Intertek's size provides capacity and global reach, but the Champaign lab's dedicated supplement focus gives it more specialization than a general-purpose lab.

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Identity TestingPotency TestingPurity TestingMicrobial TestingShelf-Life TestingAllergen TestingAdulteration Screening

Assessed Mar 2026

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Labstat International operates ISO/IEC 17025 accredited laboratories in Kitchener, Ontario (Canada) and Greensboro, North Carolina. While best known as the world's largest independent nicotine testing laboratory, Labstat has expanded into dietary supplement and natural health product testing. Their supplement testing services include identity testing, potency analysis, heavy metals, microbial testing, and stability studies. Labstat's accreditation through the Standards Council of Canada covers one of the most comprehensive lists of accredited methods among independent labs. They follow GLP principles (21 CFR Part 58) and comply with 21 CFR Part 11 for electronic records. The Greensboro, NC facility provides US-based testing with the same accredited methods. Labstat is particularly relevant for brands selling in both the US and Canadian markets, as they test for compliance with both FDA regulations and Health Canada Natural Health Product requirements.

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Identity TestingPotency TestingHeavy MetalsMicrobial TestingStability StudiesHealth Canada NHP Testing
ISO/IEC 17025 (SCC)

Assessed Mar 2026

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Frequently Asked Questions

What accreditations should a supplement testing lab have?

Look for ISO/IEC 17025 accreditation, which validates the lab's testing methods and quality management system. FDA registration is also important. Some labs carry additional accreditations like A2LA or state-specific certifications. An unaccredited lab's results carry less weight with regulators and retailers.

What is the difference between in-house and third-party testing?

In-house testing is performed by the manufacturer's own lab during production. Third-party testing is done by an independent lab with no financial relationship to the manufacturer. Both serve different purposes: in-house for production quality control, third-party for independent verification. The strongest quality programs use both.

What is the difference between accelerated and real-time stability testing?

Accelerated stability testing subjects samples to elevated temperature and humidity (typically 40°C/75% RH) for 3-6 months to predict long-term behavior. Real-time testing stores samples under normal conditions (25°C/60% RH) for 12-36 months. Accelerated testing is faster but real-time testing is more accurate. Most programs use both.

How long does supplement testing take?

Standard turnaround for identity, potency, and microbial testing is 5 to 10 business days. Heavy metals testing adds 3 to 5 days. Stability studies take 3 to 6 months (accelerated) or 12 to 24 months (real-time). Rush testing is available from most labs at premium pricing.

How much does third-party supplement testing cost?

Basic COA testing (identity, potency, microbial) costs $500 to $1,500 per batch. Heavy metals panels add $200 to $500. Full panels including pesticides and solvents can run $2,000 to $3,500. Stability studies cost $3,000 to $8,000 per product. Pricing varies by lab and number of analytes.

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