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Supplement Manufacturers in California

Last reviewed: March 31, 2026 | Next review: June 30, 2026

23 assessed manufacturers across 7 categories in California. Each profile is independently evaluated using our published assessment method.

California is the largest concentration of dietary supplement manufacturing in the United States. The state accounts for roughly 21% of all manufacturers in our directory. Southern California anchors the industry, with a cluster of contract manufacturers, testing labs, and ingredient suppliers running from Los Angeles through Orange County to San Diego.

According to IBISWorld (2026), California's vitamin and supplement manufacturing sector represents approximately $3.2 billion in revenue across an estimated 67 businesses. These figures cover the broader manufacturing category and serve as a directional proxy, not a precise count of supplement-only facilities.

Why Brands Source in California

Three factors pull supplement brands toward California manufacturers. First, port proximity. The Port of Long Beach and Port of Oakland handle a significant share of US botanical and raw material imports from Asia and South America. Manufacturers near these ports reduce transit time and freight cost for imported ingredients.

Second, talent density. California's food science programs (UC Davis, Cal Poly) and its concentration of pharmaceutical and biotech companies create a deep labor pool for quality assurance, regulatory affairs, and formulation chemistry.

Third, industry infrastructure. The Southern California Dietary Supplement Council (SCDSC), Natural Products Expo West in Anaheim, and a network of third-party testing labs create an ecosystem where manufacturers, brands, and compliance professionals are within driving distance of each other.

Major California-based manufacturers include Robinson Pharma (Santa Fe Springs, one of the largest CMs in the US by volume), GMP Labs (Anaheim), Matsun Nutrition (Irwindale), and VitaWest (Chatsworth). The Bay Area serves as a secondary node, particularly for brands focused on innovation and direct-to-consumer products.

California Regulatory Requirements

California imposes requirements beyond federal cGMP regulations. If you are manufacturing or selling supplements in California, you need to understand four additional layers.

Regulatory requirements change. Verify current requirements directly with CDPH and OEHHA before making compliance decisions.

Proposition 65 (Safe Drinking Water and Toxic Enforcement Act)

Prop 65 requires businesses to warn California consumers about significant exposures to listed chemicals. For supplement manufacturers, this primarily means testing for heavy metals. OEHHA publishes safe-harbor levels that, if met, eliminate the warning requirement.

Heavy MetalSafe Harbor LevelType
Lead (Pb)0.5 mcg/dayMADL (reproductive)
Cadmium (Cd)4.1 mcg/dayNSRL (cancer)
Arsenic (As)10 mcg/dayNSRL (cancer)
Mercury (Hg)No established safe harborEvaluate per product

Source: OEHHA Proposition 65 Safe Harbor Levels

These thresholds are more stringent than federal requirements under 21 CFR Part 111. A product that passes federal testing may still require a Prop 65 warning label in California.

SB 646: Third-Party Testing for Dietary Supplements

Signed into law in 2025, SB 646 requires third-party testing of dietary supplements sold in California, with enforcement beginning January 2027. The bill mandates independent laboratory testing (not manufacturer self-testing) for identity, contaminants, and label accuracy. This goes beyond the federal cGMP requirement, which allows manufacturers to conduct their own testing.

Source: CA Senate: Protein Safety Bill

SB 1033: Supplement Disclosure Requirements (Active Bill)

SB 1033 is currently in committee and has not been signed into law. If passed, it would expand disclosure requirements for supplement manufacturers selling in California, including additional labeling for certain ingredients. Because this bill is still being debated, the final requirements may change. We will update this section when the bill's status changes.

Legislative status: in committee (as of March 2026)

Processed Food Registration (PFR)

California requires a Processed Food Registration from the California Department of Public Health (CDPH) for any facility that processes, packages, or labels food products in-state. Dietary supplements count as food products under California law. This registration is in addition to federal FDA facility registration. If your manufacturer is located in California, confirm they hold a current PFR.

SB 54: Packaging Extended Producer Responsibility

SB 54 (the Plastic Pollution Prevention and Packaging Producer Responsibility Act) creates extended producer responsibility requirements for packaging sold in California. Supplement brands using plastic bottles, blister packs, or pouches may need to register with CalRecycle and meet recycling rate targets. The law is being phased in through 2032. Ask your packaging provider about SB 54 compliance for your specific packaging format.

Minimum Order Quantities: California Is Not One Market

One of the most common questions from new supplement brands is whether they can find a manufacturer willing to do a small run. California has manufacturers at every scale, but you need to match your volume to the right partner.

ManufacturerTypical MOQNotes
VitaWest~10 bottles (stock)Stock formulas only at this volume
Jinher Health Sciences~1,500 units (custom)Custom formulation available
Matsun Nutrition~2,500 unitsCapsules, tablets, powders
Superior Supplement Manufacturing~250,000 tabletsHigh-volume production

Stock formulas (also called private label) let you start with very small quantities because the manufacturer already has the formula, ingredients, and production setup. Custom formulation requires dedicated ingredient sourcing and equipment configuration, which drives MOQs higher.

If you are testing a new product concept, consider starting with a stock formula to validate demand before investing in custom formulation. See our guide to supplement costs for detailed cost breakdowns by dosage form and volume tier, or use the First Run Cost Estimator for a rough budget estimate.

How We Assess These Manufacturers

Every manufacturer listed below has been independently assessed using our published 6-gate assessment method. We verify certifications against independent databases (NSF, SQF, USDA, A2LA) where available. Certification statuses are marked as “confirmed” (independently verified) or “self-reported” (claimed by the manufacturer but not yet independently confirmed).

We do not accept payment for placement or ranking. See how we get paid for our current revenue model. If you are a manufacturer and your information needs updating, use our listing claim form.

Valencia, California

How We Get Paid

Lief Labs operates over 220,000 sq ft of manufacturing space across two FDA-registered facilities in Valencia, California. The company claims USDA Organic certification and operates an ISO/IEC 17025 accredited microbiology lab. This in-house testing capability is unusual for contract manufacturers and allows faster quality control turnaround. They produce over 5 million capsules and 1 million tablets per day. Lief Labs reports holding NSF International cGMP certification since 2010, though this could not be confirmed through NSF's public GMP directory as of March 2026. Their product line includes organic-approved tablets, a category few competitors offer. The company also provides Non-GMO Project verification assistance for brands seeking that certification. They target emerging and entrepreneurial brands with minimum orders starting at 2,500 units.

Min. Order

2,500 units

Lead Time

8-10 weeks (capsules and powders; varies by ingredient sourcing)

CapsulesTabletsPowdersGummies
capsulesgummiespowders+1 more

Assessed Mar 2026

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Santa Ana, California

How We Get Paid

Robinson Pharma operates over 1 million sq ft of manufacturing space across eight to nine facilities in Santa Ana and Costa Mesa, California. Founded in 1989, the company has the largest softgel production capacity in the United States. Their facilities produce 23 billion softgels, 7 billion gummies, and 5 billion tablets and capsules per year. Robinson Pharma reports certifications from NSF, UL, and Eurofins, and carries ISO 9001:2015 and SQF credentials, though NSF and USP could not be confirmed through their respective public directories as of March 2026. USDA Organic certification has been independently confirmed via the USDA Organic Integrity Database. The company recently expanded with new high-speed liquid production lines and additional tablet capabilities. They serve brands that need high-volume production runs with claims of the shortest lead times in the industry. Their facility count has grown from seven to nine buildings in recent years, funded partly by a $40.7 million property acquisition.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

SoftgelsGummiesTabletsCapsulesPowdersLiquids
capsulesgummiesliquids+3 more
SQF CertifiedUSDA Organic

Assessed Mar 2026

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Best Formulations has manufactured dietary supplements and softgels from City of Industry, California since 1984. The company was acquired by Sirio Pharma in 2023 and now operates as Sirio Americas. This gives them access to a global network spanning Asia and Europe. Best Formulations is one of the largest plant-based softgel manufacturers in the United States. They specialize in difficult paste-style softgel formulas and probiotic handling. The company holds an FDA drug license, which is a higher regulatory standard than standard dietary supplement registration. Their four Southern California facilities total over 120,000 sq ft. They also report NPA GMP certification and NSF GMP for Sport designation, making them suitable for sports nutrition brands. The Sirio acquisition brings institutional-grade resources but may add corporate complexity for smaller brands.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

SoftgelsTabletsCapsulesPowdersGummiesLiquids
capsulesgummiesliquids+3 more
NSF GMP for Sport

Assessed Mar 2026

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Captek Softgel International (CSI) specializes in softgel and gummy manufacturing from facilities in Cerritos, Vista, and La Mirada, California. Founded in 1996, the company employs roughly 700 people and has produced over 4,000 formulations. They developed MarineGel, a marine-sourced softgel alternative to traditional bovine and porcine gelatin. This product is naturally suited for Halal and Kosher markets. Captek reports SQF certification for its 60,000 sq ft gummy facility in La Mirada with a starch-free production line. They hold independently confirmed NSF GMP certification and report NSF GMP for Sport designation. The company maintains over 160 bulk stock SKUs with low minimum order quantities for brands that want to launch quickly. Captek received private equity investment from Swander Pace Capital. They are one of the largest independent softgel contract manufacturers in the United States.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

SoftgelsGummiesCapsules
capsulesgummiessoftgels
NSF GMP CertifiedSQF Certified

Assessed Mar 2026

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GMP Laboratories of America is a contract manufacturer of dietary supplements and homeopathic drug products based in Anaheim, California, operating since 1994. The company runs two facilities totaling over 100,000 square feet within the Anaheim Center for Advanced Technology. GMP Labs produces capsules, tablets, powders, liquids, and gummies, with a stated hard-shell encapsulation capacity exceeding 400 million capsules per month. The company holds USDA Organic certification through CCOF and NSF GMP for Sport registration. GMP Labs offers end-to-end services from custom formulation and R&D through manufacturing, packaging, and labeling, including Amazon FBA-compliant packaging and blister card packaging.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

CapsulesTabletsPowdersGummiesLiquidsSoftgels
capsulesgummiesliquids+3 more
NSF Certified for SportUSDA Organic

Assessed Mar 2026

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Riverside, California

How We Get Paid

Kelker Pharma, Inc. is a contract manufacturer of dietary supplements based in Riverside, California, operating from a 75,000-square-foot facility. Founded by Tariq Kelker, M.D. (a trauma surgeon and formulation specialist), the company manufactures capsules, tablets, powders, and nutritional bars for brands in sports nutrition, weight management, and general health. The company reports a production capacity of 10 million capsules and 5 million tablets per day. In 2025, Kelker launched its own consumer brand, NUTRILINQ, focused on nutritional support for GLP-1 medication users. Kelker claims cGMP, FDA registration, USDA Organic (via Oregon Tilth), and NSF GMP/Sport certifications. NSF/ANSI 455-2 (GMP) and USDA Organic certifications were independently confirmed through public directory searches; remaining certifications are self-reported.

Min. Order

Not publicly disclosed (website states 'low minimums')

Lead Time

Not publicly disclosed

CapsulesTabletsPowdersNutritional Bars
capsulespowderstablets
NSF/ANSI 455-2 (GMP)USDA Organic

Assessed Mar 2026

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Matsun Nutrition is an FDA-registered contract manufacturer based in Murrieta, California, specializing in liquid dietary supplements. Founded in 1992, they have over three decades of experience in liquid vitamin and supplement manufacturing. Their facility is cGMP and ISO 9001 certified with Eurofins registration. Product formats include liquid vitamins, drops, shots, powders, gummies, and capsules. They offer low minimum order quantities starting at 12 bottles for private label, with 1-2 day shipping on in-stock formulas and 24/7 facility operations for rush jobs. They also provide custom formulation, label design, product rendering, and fulfillment services.

Min. Order

12 bottles (private label)

Lead Time

1-2 days (in-stock), custom varies

LiquidsCapsulesPowdersGummiesDropsShots
capsulesgummiesliquids+1 more

Assessed Mar 2026

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Rancho Cucamonga, California

How We Get Paid

VIP Solutions (VIP Inc.) is a packaging and assembly services provider based in Rancho Cucamonga, California. The company operates 100,000 square feet of warehouse space with a workforce of over 400 employees and provides hand assembly, repack/rework, blister packaging, shrink wrapping, labeling, and distribution services. VIP Solutions serves brands across multiple industries including dietary supplements. The company also operates a facility in Hesperia, California. VIP Solutions holds CARF accreditation as a vocational improvement program that provides employment opportunities for persons with disabilities.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Blister PackagingShrink WrappingLabelingHand AssemblyRepack/ReworkDistribution

Assessed Mar 2026

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San Marcos, California

How We Get Paid

Pack Lab is a contract packaging company in San Marcos, California, established in 1991. The company operates a 30,000-square-foot facility and specializes in dietary supplement, nutraceutical, and OTC drug packaging. Pack Lab reports capacity of 100,000 bottles per day and 150,000 packets per day. The company holds FDA registration and follows cGMP practices, with OTC drug packaging certification indicating a higher compliance bar than supplement-only operations. Pack Lab provides bottle filling, labeling, pouching, stick pack filling, and shrink wrapping services. The Southern California location is convenient for brands with West Coast contract manufacturers.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Bottle FillingLabelingPouchingStick Pack FillingShrink WrappingOTC Drug Packaging

Assessed Mar 2026

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San Bernardino, California

How We Get Paid

Teamwork Packaging is a packaging services provider in San Bernardino, California, with over 30 years of experience in shrink wrapping and secondary packaging. The company offers both manual and automated shrink wrapping, shrink sleeving, assembly, and repackaging services for dietary supplements and consumer products. Located approximately 15 miles from VIP Solutions in Rancho Cucamonga, Teamwork Packaging serves the Southern California manufacturing corridor. The company handles supplement bottles, multipacks, and promotional bundles.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Shrink WrappingShrink SleevingAssemblyRepackagingMultipack Assembly

Assessed Mar 2026

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Multi-Pak Corporation has operated from its 55,000-square-foot facility in Chatsworth, California, since 1954. The company specializes in unit dose packaging formats including sachets, blister cards, daily dose packets, and stick packs. Multi-Pak is a pure-play packaging company; not a contract manufacturer that also offers packaging. Over 70 years of continuous operation is a longevity signal that few packaging providers can match. The company holds FDA registration and cGMP compliance. Located in the San Fernando Valley, Multi-Pak serves the Southern California supplement manufacturing corridor.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Unit Dose PackagingSachetsBlister CardsDaily Dose PacketsStick Packs
sachetsstick-packs

Assessed Mar 2026

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Brand Nutra is a contract supplement manufacturer and packaging company based in Vista, California, providing a turnkey solution from formulation through secondary packaging. Their packaging capabilities include solid-dose and powder bottle filling, stick pack filling, pressure-sensitive label application, full-body shrink sleeve application, induction sealing, metal detection, lot code and expiry date stamping, tamper-evident neck band application, cartoning, and case packing — all on integrated packaging lines. Brand Nutra has designed over 1,000 dietary supplement labels with FDA-compliant Nutrition Facts panels. Secondary packaging services include shrink wrapping, bundling, and custom pack-out options. The company handles HDPE and PET bottles in various shapes, sizes, and colors.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Bottle Filling (Solid Dose + Powder)Shrink Sleeve ApplicationLabel ApplicationStick Pack FillingTamper-Evident Neck BandsCartoning and Case Packing

Assessed Mar 2026

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Stauber Performance Ingredients is a national ingredient supplier and distributor serving the nutritional, food, beverage, pharmaceutical, cosmetic, and pet care industries since 1969. Operating from headquarters in Fullerton, California with a manufacturing facility in New York and warehouses in four strategic US locations, Stauber offers over 400 ingredients spanning vitamins, minerals, botanicals, probiotics, amino acids, and specialty compounds. Their Performance Processing division, added in 2012, provides in-house blending, granulation, milling, and instantizing capabilities with a full analytical lab.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

VitaminsMineralsBotanical ExtractsProbioticsAmino AcidsSpecialty IngredientsProteinsEnzymes
SQF Level 2 (Food Safety)

Assessed Mar 2026

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Gardena, California

How We Get Paid

NP Nutra (Nature's Power Nutraceuticals Corp.) is a wholesale-only supplier of premium nutraceutical ingredients, botanical extracts, superfruits, and proprietary blends. Founded in 1998, the company offers over 130 ingredients sourced from partner facilities in the USA, Brazil, Chile, China, India, Indonesia, Peru, and other countries. NP Nutra developed the proprietary Triple-T Verification program for supply chain traceability; covering origin tracking, quality testing, and vendor certification. Their Nutra Organics line includes 80+ certified organic ingredients.

Min. Order

5 kg minimum (wholesale only)

Lead Time

Not publicly disclosed

Botanical ExtractsSuperfruit PowdersWhole Food PowdersPlant-Based ProteinsOrganic IngredientsLiquid Extracts
liquidspowders

Assessed Mar 2026

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City of Industry, California

How We Get Paid

AIDP (Advanced Ingredients for Dietary Products) is a specialty ingredient company focused on clinically studied, branded functional ingredients for the nutrition, food, and beverage markets. Founded in 1996 and based in City of Industry, California, AIDP maintains a portfolio of 40+ branded ingredients and over 200 commodity ingredients covering cognitive health, digestive health, bone and joint support, plant proteins, and more. Notable branded ingredients include Magtein (magnesium L-threonate for cognition), PreticX (XOS prebiotic with 12+ human studies), and KoACT (collagen-calcium complex for bone density).

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Branded Functional IngredientsPrebioticsProbioticsMineralsCollagensPlant ProteinsVitaminsBotanical Extracts
NSF GMP Registered

Assessed Mar 2026

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Niagen Bioscience (NASDAQ: NAGE), formerly ChromaDex, is a publicly traded bioscience company that pioneered the commercialization of nicotinamide riboside (NR), an NAD+ precursor. Their flagship ingredient Niagen (nicotinamide riboside chloride) is patented, clinically proven to increase cellular NAD+ by up to 150%, and has received FDA NDI notification. The company holds licensed patents from Cornell University, Dartmouth College, and Washington University in St. Louis. Niagen Bioscience also sells Tru Niagen directly to consumers. The company was renamed from ChromaDex to Niagen Bioscience in March 2025. Based in Los Angeles, California.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Nicotinamide Riboside (Niagen)NAD+ Precursor Ingredients

Assessed Mar 2026

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Garden Grove, California

How We Get Paid

Alkemist Labs is an independent botanical and mushroom testing laboratory in Garden Grove, California. Founded by Elan Sudberg, the company specializes in identity and potency testing for natural products using HPTLC (High Performance Thin-Layer Chromatography), microscopy, and HPLC methods. Their ISO/IEC 17025 accreditation through A2LA specifically covers dietary supplement and botanical identification; a focused scope that reflects their deep specialization. Alkemist Labs maintains one of the largest collections of analyzed and verified botanical reference materials in the industry, containing over 15,000 specimens spanning 20 years. This collection is critical for identity testing accuracy. AG1 (Athletic Greens) is a notable client. Alkemist publishes a biannual report on the top botanicals and fungi that commonly fail identity testing, providing transparency that is rare in the testing industry. They are a smaller, specialized lab compared to Eurofins or SGS, which means more personalized service but potentially longer wait times during peak demand.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Botanical Identity TestingPotency TestingHPTLC AnalysisMicroscopyMushroom Testing
ISO/IEC 17025 (A2LA)

Assessed Mar 2026

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Qalitex Laboratories reports ISO/IEC 17025 accreditation for its dietary supplement, cosmetic, and consumer goods testing laboratory with facilities in Irvine and San Diego, California. Their A2LA accreditation scope covers identity, potency, heavy metals (ICP-MS), microbiology (USP methods), and pesticide testing for dietary supplements. Qalitex also offers preservative efficacy testing, stability studies under ICH guidelines, and regulatory compliance support. Testing programs are designed to meet 21 CFR Part 111, California Proposition 65, Amazon compliance, and Health Canada NHP Directorate standards. Standard panel turnaround starts at 48 hours. Qalitex publishes educational resources on ISO 17025 accreditation and independent lab testing, including a March 2026 guide for testing labs seeking accreditation.

Min. Order

Lead Time

48 hours for standard panels

Identity TestingPotency TestingHeavy Metal AnalysisMicrobiology TestingStability Studies

Assessed Mar 2026

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San Francisco, California

How We Get Paid

Anresco Laboratories is a family-owned analytical testing company founded in 1943 in San Francisco, California, with over 82 years of experience. The company is ISO/IEC 17025:2017 accredited and recognized by the FDA. Anresco operates its headquarters and primary laboratory in San Francisco with branch offices in Los Angeles, New York, and Fort Lauderdale. In a recent strategic move, Anresco united with NJ Labs to form a nationwide testing network, expanding their geographic coverage. Their testing capabilities span food safety, cannabis compliance, and dietary supplement validation, including identity, potency, contaminant, and microbiological testing. Anresco was also an exhibitor at SupplySide Global 2025.

Min. Order

Lead Time

Not publicly disclosed

Identity TestingPotency TestingContaminant ScreeningMicrobiology TestingNutritional Labeling

Assessed Mar 2026

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Irvine, California

How We Get Paid

Nutralliance is a dietary supplement R&D and formulation consultancy based in Irvine, California. The company provides formulation services, ingredient sourcing, regulatory guidance, and product development support for supplement brands. Unlike full-service CMOs, Nutralliance focuses on the front-end product development phase; helping brands design formulas, select ingredients, navigate regulatory requirements, and prepare products for manufacturing. They also offer stability study coordination and clinical trial design assistance.

Min. Order

Project-based (consulting)

Lead Time

Not publicly disclosed

Formulation ConsultingCapsulesTabletsPowdersSoftgelsBeverages
capsulespowderssoftgels+1 more

Assessed Mar 2026

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San Clemente, California

How We Get Paid

Nutri-Con is a supplement industry consulting firm based in San Clemente, California, specializing in product development and formulation services. Founded by industry veterans, Nutri-Con helps brands with custom formula design, ingredient selection, product positioning, and regulatory compliance for dietary supplements. They serve as an independent product development partner, providing expertise across multiple dosage forms and ingredient categories without the conflicts of interest that can arise when CMOs also provide formulation services.

Min. Order

Project-based (consulting)

Lead Time

Not publicly disclosed

Formulation ConsultingCapsulesTabletsPowdersSoftgelsGummies
capsulesgummiespowders+2 more

Assessed Mar 2026

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Gold Coast Ingredients (GCI) is a wholesale flavor and color manufacturer founded in 1985, operating facilities in California and Pennsylvania. The company serves the nutraceutical, food, beverage, oral care, and cosmetics industries with custom formulations in powder, spray-dried (encapsulated), freeze-dried, liquid, emulsion, and extract formats. Gold Coast's R&D team specializes in flavoring protein beverages, supplements, nutrition bars, energy drinks, and vitamins. They provide custom masking agents and sweetness enhancers designed to reduce unwanted tastes and bitterness from natural ingredients like stevia, vegetable protein, amino acids, and fish oil. GCI maintains QAI organic, ISA Halal, and OU/KOF-K Kosher certifications.

Min. Order

Not publicly disclosed

Lead Time

Not publicly disclosed

Liquid FlavorsDry/Powder FlavorsSpray-Dried FlavorsFlavor Masking AgentsSweetness EnhancersColors
liquidspowders

Assessed Mar 2026

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Carlsbad Technology is a dietary supplement regulatory consulting firm with nearly three decades of experience. Their team includes former FDA compliance and inspection officials, pharmacists, formulation specialists, and quality assurance experts. The company specializes in NDI (New Dietary Ingredient) notifications, FDA labeling compliance, cGMP auditing, quality systems evaluation, and regulatory strategy for supplement companies. Carlsbad Technology helps companies navigate the FDA pre-market notification process for products containing ingredients not marketed in the US prior to October 1994. Based in California, the firm serves companies at all stages from startups entering the supplement market to established brands facing regulatory challenges.

Min. Order

Lead Time

Not publicly disclosed

Assessed Mar 2026

View Profile →

Dietary supplement manufacturers must comply with 21 CFR Part 111 (Current Good Manufacturing Practice for dietary supplements). This includes requirements for personnel, facilities, equipment, production, laboratory operations, and record-keeping.

Frequently Asked Questions

Do California supplement manufacturers need to comply with Prop 65?

Yes. California's Proposition 65 (the Safe Drinking Water and Toxic Enforcement Act of 1986) requires businesses to warn consumers about significant exposures to chemicals that cause cancer or reproductive harm. Supplement manufacturers selling in California must test for heavy metals and other listed substances. OEHHA publishes safe-harbor levels: lead (0.5 mcg/day MADL), cadmium (4.1 mcg/day NSRL), arsenic (10 mcg/day NSRL), and mercury (no established safe harbor, evaluate on a per-product basis). These thresholds are more stringent than federal requirements under 21 CFR Part 111.

What is a Processed Food Registration and do California manufacturers need one?

A Processed Food Registration (PFR) is a state-level license required by the California Department of Public Health (CDPH) for any facility that processes, packages, or labels food products in California. Dietary supplements manufactured in-state need a PFR in addition to federal FDA registration. The PFR does not apply to out-of-state manufacturers shipping into California.

How do minimum order quantities vary among California manufacturers?

California manufacturers span a wide range. VitaWest offers stock formula runs starting at 10 bottles. Jinher Health Sciences starts custom formulation at around 1,500 units. Matsun Nutrition typically requires 2,500 units minimum. Superior Supplement Manufacturing works at higher volumes, starting around 250,000 tablets. If you are testing a new product, look for manufacturers offering stock formulas or small-batch custom runs before committing to large-scale production.

What certifications should I look for in a California supplement manufacturer?

At minimum: FDA registration and cGMP compliance under 21 CFR Part 111 are legally required. Beyond that, third-party certifications add independent verification. NSF International GMP is the most common third-party audit for supplement facilities. NSF Certified for Sport or Informed Sport matter if your products target athletes. Organic (USDA NOP) or Non-GMO Project verification apply to specific product claims. Check our certification pages for details on what each certification proves and does not prove.

Is California more expensive for supplement manufacturing than other states?

Operating costs in California are higher than many states due to real estate, labor rates, energy costs, and Prop 65 compliance testing. Some manufacturers pass these costs through; others absorb them. California does offer proximity to major ingredient import ports (Long Beach, Oakland), a large local talent pool in food science and quality assurance, and direct access to the largest US consumer market. Whether the premium is worth it depends on your supply chain priorities and where your customers are located.

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Every vendor evaluated against our published 6-gate assessment method. No paid placements.